The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system

@article{Wiercinska2010TheTP,
  title={The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system},
  author={Eliza Wiercinska and Hildegonda P. H. Naber and Evangelia Pardali and Gabri van der Pluijm and Hans van Dam and Peter ten Dijke},
  journal={Breast Cancer Research and Treatment},
  year={2010},
  volume={128},
  pages={657-666}
}
Transforming growth factor-β (TGF-β) has opposing roles in breast cancer progression by acting as a tumor suppressor in the initial phase, but stimulating invasion and metastasis at later stages. In contrast to the mechanisms by which TGF-β induces growth arrest, the pathways that mediate tumor invasion are not well understood. Here, we describe a TGF-β-dependent invasion assay system consisting of spheroids of MCF10A1 normal breast epithelial cells (M1) and RAS-transformed (pre-)malignant… CONTINUE READING

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