The TBP–PP2A mitotic complex bookmarks genes by preventing condensin action

@article{Xing2008TheTM,
  title={The TBP–PP2A mitotic complex bookmarks genes by preventing condensin action},
  author={Hongyan Xing and Nathan L Vanderford and Kevin D. Sarge},
  journal={Nature Cell Biology},
  year={2008},
  volume={10},
  pages={1318-1323}
}

• Hongyan Xing, Nathan L Vanderford, Kevin D. Sarge
• Published in Nature Cell Biology 2008
• DOI:10.1038/ncb1790

To maintain phenotypes of cell lineages, cells must 'remember' which genes were active before mitosis entry and transmit this information to their daughter cells so that expression patterns can be faithfully re-established in G1. This phenomenon is called gene bookmarking. However, during mitosis transcription ceases, most sequence-specific proteins dissociate from DNA and the chromatin is tightly compacted, making it difficult to understand how gene activity 'memory' is maintained through this… CONTINUE READING

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