The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-gamma-mediated inhibition in human chondrocytes: requirement for Stat1 alpha, Jak1 and Jak2.

@article{Osaki2003TheTC,
  title={The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-gamma-mediated inhibition in human chondrocytes: requirement for Stat1 alpha, Jak1 and Jak2.},
  author={Makoto Osaki and Lujian Tan and Bob K. Choy and Yasuhiro Yoshida and Kathryn S E Cheah and Philip E. Auron and Mary B Goldring},
  journal={The Biochemical journal},
  year={2003},
  volume={369 Pt 1},
  pages={
          103-15
        }
}
Interferon-gamma (IFN-gamma) inhibits the synthesis of the cartilage-specific extracellular matrix protein type II collagen, and suppresses the expression of the type II collagen gene ( COL2A1 ) at the transcriptional level. To further examine this mechanism, the responses of COL2A1 regulatory sequences to IFN-gamma and the role of components of the Janus kinase/signal transducer and activators of transcription (JAK/STAT) pathway were examined in the immortalized human chondrocyte cell line, C… CONTINUE READING

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