The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.

@article{Saint2014TheTC,
  title={The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.},
  author={Malika Saint and Sonal Sawhney and Ishani Sinha and Rana P Singh and Rashmi Dahiya and Anushikha Thakur and Rahul Siddharthan and Krishnamurthy Natarajan},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 9},
  pages={1547-63}
}
A common function of the TFIID and SAGA complexes, which are recruited by transcriptional activators, is to deliver TBP to promoters to stimulate transcription. Neither the relative contributions of the five shared TBP-associated factor (TAF) subunits in TFIID and SAGA nor the requirement for different domains in shared TAFs for transcriptional activation is well understood. In this study, we uncovered the essential requirement for the highly conserved C-terminal region (CRD) of Taf9, a shared… CONTINUE READING
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