The T4 phage DNA mimic protein Arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS.

@article{Ho2014TheTP,
  title={The T4 phage DNA mimic protein Arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS.},
  author={C Ho and Hao-Ching Wang and T P Ko and Yuan-Chih Chang and Andrew H-J Wang},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 39},
  pages={27046-54}
}
The T4 phage protein Arn (Anti restriction nuclease) was identified as an inhibitor of the restriction enzyme McrBC. However, until now its molecular mechanism remained unclear. In the present study we used structural approaches to investigate biological properties of Arn. A structural analysis of Arn revealed that its shape and negative charge distribution are similar to dsDNA, suggesting that this protein could act as a DNA mimic. In a subsequent proteomic analysis, we found that the… CONTINUE READING
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