The T-cell receptor zeta chain contains a GTP/GDP binding site.

  title={The T-cell receptor zeta chain contains a GTP/GDP binding site.},
  author={Marcus E Peter and Craig G. Hall and A. R{\"u}hlmann and Jaime Ferrer Sancho and Cox Terhorst},
  journal={The EMBO journal},
  volume={11 3},
In a search for nucleotide binding proteins associated with the T-cell receptor (TCR)-CD3 complex, a novel labeling technique involving introduction of [alpha-32P]GTP or [alpha-32P]ATP into permeabilized cells followed by in situ periodate oxidation was developed. To test the method we first demonstrated that p21ras and other classical GTP binding proteins could be labeled in a GTP-specific manner. In human T lymphocytes the TCR zeta chain was found to be specifically labeled by GTPoxi but not… CONTINUE READING


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