The T cell receptor beta-chain second complementarity determining region loop (CDR2beta governs T cell activation and Vbeta specificity by bacterial superantigens.

@article{Rahman2011TheTC,
  title={The T cell receptor beta-chain second complementarity determining region loop (CDR2beta governs T cell activation and Vbeta specificity by bacterial superantigens.},
  author={A K M Nur-ur Rahman and Daniel A. Bonsor and Christine A. Herfst and Fraser Pollard and Michael Peirce and Aaron W Wyatt and Katherine J. Kasper and Joaqu{\'i}n Madrenas and Eric J Sundberg and John K McCormick},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 6},
  pages={4871-81}
}
Superantigens (SAgs) are microbial toxins defined by their ability to activate T lymphocytes in a T cell receptor (TCR) β-chain variable domain (Vβ)-specific manner. Although existing structural information indicates that diverse bacterial SAgs all uniformly engage the Vβ second complementarity determining region (CDR2β) loop, the molecular rules that dictate SAg-mediated T cell activation and Vβ specificity are not fully understood. Herein we report the crystal structure of human Vβ2.1 (hVβ2.1… CONTINUE READING
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