The T cell factor/beta-catenin antagonist PKF115-584 inhibits proliferation of adrenocortical carcinoma cells.


CONTEXT Mutations of the beta-catenin (CTNNB1) gene are frequently found in adrenocortical tumors. This has important consequences to deregulate the expression of transcriptional targets of the Wnt pathway, which may contribute to tumorigenesis. OBJECTIVE The objective of the study was to investigate the effect of the small-molecule inhibitor of the T… (More)
DOI: 10.1210/jc.2008-0247

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