The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck.

@article{Raab1994TheTA,
  title={The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck.},
  author={Marc S Raab and Masayuki Yamamoto and Christopher E. Rudd},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 5},
  pages={2862-70}
}
CD5 is a T-cell-specific antigen which binds to the B-cell antigen CD72 and acts as a coreceptor in the stimulation of T-cell growth. CD5 associates with the T-cell receptor zeta chain (TcR zeta)/CD3 complex and is rapidly phosphosphorylated on tyrosine residues as a result of TcR zeta/CD3 ligation. However, despite this, the mechanism by which CD5 generates intracellular signals is unclear. In this study, we demonstrate that CD5 is coupled to the protein-tyrosine kinase p56lck and can act as a… CONTINUE READING

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