The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells.

@article{Kinoshita1997TheTC,
  title={The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells.},
  author={Shigemi Kinoshita and Li Su and Mariane Tami Amano and Luika A. Timmerman and Hideto Kaneshima and Garry P. Nolan},
  journal={Immunity},
  year={1997},
  volume={6 3},
  pages={235-44}
}
Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) infection is associated with increased levels of viral replication and burden in the peripheral blood and lymphoid organs. T cell activation and ensuing cellular gene activation can be critical for HIV-1 replication. The hypothesis that the nuclear factor of activated T cells (NF-AT) may influence HIV-1 replication is therefore compelling given the tight correlation of HIV-1 transcriptional induction to T cell activation. We… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 107 extracted citations

Similar Papers

Loading similar papers…