The T allele of the missense Glu(298)Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile.

@article{Gardemann2002TheTA,
  title={The T allele of the missense Glu(298)Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile.},
  author={Andreas Gardemann and Jana Lohre and Sevim Cayci and Norbert Katz and Harald Tillmanns and Werner G Haberbosch},
  journal={Atherosclerosis},
  year={2002},
  volume={160 1},
  pages={
          167-75
        }
}
AIMS Nitric oxide (NO) plays a protective role during atherogenesis. In the endothelium, NO is synthesised by the constitutive NO synthase (ecNOS). We analysed the relation of the ecNOS Glu(298)Asp and 4a/b gene polymorphisms to coronary artery disease (CAD) and myocardial infarction (MI) in a population of 3250 German subjects (533 healthy controls and 2717 individuals who underwent coronary angiography). RESULTS Although in the total sample, the ecNOS T allele was not associated with the… CONTINUE READING
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