The T Box Transcription Factor No Tail in Ciliated Cells Controls Zebrafish Left-Right Asymmetry

@article{Amack2004TheTB,
  title={The T Box Transcription Factor No Tail in Ciliated Cells Controls Zebrafish Left-Right Asymmetry},
  author={Jeffrey D Amack and H Joseph Yost},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={685-690}
}
The heart, brain, and gut develop essential left-right (LR) asymmetries. Specialized groups of ciliated cells have been implicated in LR patterning in mouse, chick, frog, and zebrafish embryos. In zebrafish, these ciliated cells are found in Kupffer's vesicle (KV) and are progeny of dorsal forerunner cells (DFCs). However, there is no direct evidence in any vertebrate that the genes involved in LR development are specifically required in ciliated cells. By using a novel method in zebrafish, we… CONTINUE READING

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