The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients.

@article{Rossi2003TheTA,
  title={The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients.},
  author={Gian Paolo Rossi and Stefano Taddei and Agostino Virdis and Martina Cavallin and Lorenzo Ghiadoni and Stefania Favilla and Daniele Versari and Isabella Sudano and Achille Cesare Pessina and Antonio Salvetti},
  journal={Journal of the American College of Cardiology},
  year={2003},
  volume={41 6},
  pages={938-45}
}
OBJECTIVES We sought to investigate whether two polymorphisms located in the promoter (T(-786)C) and exon 7 (Glu298Asp) of the endothelial nitric oxide (NO) synthase (eNOS) gene affected agonists-mediated NO release. BACKGROUND Endothelial dysfunction can be genetically determined. Therefore, we investigated whether two polymorphisms located in the eNOS gene affected agonists-mediated NO release. METHODS We compared endothelial-dependent and -independent vasodilation of the different eNOS… CONTINUE READING

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