The T-786-->C mutation in endothelial nitric oxide synthase is associated with hypertension.

@article{Hyndman2002TheTM,
  title={The T-786-->C mutation in endothelial nitric oxide synthase is associated with hypertension.},
  author={Matthew Eric Hyndman and Howard G. Parsons and Subodh Verma and Peter J. Bridge and S. M. Edworthy and Charlotte Maughan Jones and Eva M. Lonn and François Charbonneau and Todd J. Anderson},
  journal={Hypertension},
  year={2002},
  volume={39 4},
  pages={919-22}
}
Although the pathogenic mechanisms involved in predisposing individuals to hypertension are not well defined, evidence is accumulating that suggests a strong genetic transmission. Animal studies and some clinical investigations have revealed that aberrant NO production may be an important contributing factor. Indeed, a missense mutation in the endothelial… CONTINUE READING