The Systemic Pro-Inflammatory Response in Sepsis

  title={The Systemic Pro-Inflammatory Response in Sepsis},
  • Published 2010
The systemic inflammatory response syndrome (SIRS) is the predominantly cytokine-mediated, pro-inflammatory response of the host to invading pathogens and is considered the hallmark sign of sepsis. Molecular components of this response can be divided into cytokines, plasma cascades and acute phase proteins while the predominant cellular components are leukocytes and the endothelium. Highthroughput genetic profiling studies have led to increased insights into leukocyte regulation during sepsis… CONTINUE READING