The Synthetic Androgen Methyltrienolone (R1881) Acts as a Potent Antagonist of the Mineralocorticoid Receptor

@article{Takeda2007TheSA,
  title={The Synthetic Androgen Methyltrienolone (R1881) Acts as a Potent Antagonist of the Mineralocorticoid Receptor},
  author={Armelle-Natsuo Takeda and Grégory Maurice Pinon and Marcelle Bens and J{\'e}r{\^o}me Fagart and Marie-Edith Rafestin-Oblin and Alain Vandewalle},
  journal={Molecular Pharmacology},
  year={2007},
  volume={71},
  pages={473 - 482}
}
Aldosterone binds to the mineralocorticoid receptor (MR) and exerts fine control over Na+ absorption in renal collecting duct cells (CCDs). Many natural and synthetic steroids can also bind to the MR to produce agonist or antagonist effects. Here, we investigate whether androgenic hormones act as MR agonist or antagonist ligands in CCDs. Testosterone (T), dihydrotestosterone (DHT), and methyltrienolone (R1881), a synthetic androgen agonist, all bind to the MR. R1881 displayed the same affinity… 

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