The Synthesis of Two Regioisomeric Aldehydes with a Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent-Free Intramolecular 1,3-Dipolar Cycloaddition Reactions

@article{Tenora2016TheSO,
  title={The Synthesis of Two Regioisomeric Aldehydes with a Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent-Free Intramolecular 1,3-Dipolar Cycloaddition Reactions},
  author={Luk{\'a}{\vs} Tenora and S. Man and E. V. D. Berge and M. Pot{\'a}{\vc}ek},
  journal={Synthesis},
  year={2016},
  volume={48},
  pages={2429-2437}
}
  • Lukáš Tenora, S. Man, +1 author M. Potáček
  • Published 2016
  • Chemistry
  • Synthesis
  • The paper describes the synthesis of two regioisomeric 2-amino-3-formyl- and 3-amino-2-formyl-substituted derivatives of tetrahydrobenzo[ b ]thiophene and their subsequent thermally initiated reactions with secondary amines to give azomethine ylides that undergo intramolecular 1,3-dipolar cycloadditions. In this way, two series of new fused heterocyclic compounds with three stereogenic centers were prepared. The compounds were identified and their structures were determined. 
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