The Synergistic Effects of Alcohol and Tobacco Consumption on the Risk of Esophageal Squamous Cell Carcinoma: A Meta-Analysis

  title={The Synergistic Effects of Alcohol and Tobacco Consumption on the Risk of Esophageal Squamous Cell Carcinoma: A Meta-Analysis},
  author={A. Prabhu and K. Obi and J. Rubenstein},
  journal={The American Journal of Gastroenterology},
  • A. Prabhu, K. Obi, J. Rubenstein
  • Published 2014
  • Medicine
  • The American Journal of Gastroenterology
  • OBJECTIVES:Tobacco and alcohol use are established risk factors for esophageal squamous cell carcinoma (ESCC). We sought to determine whether these factors act synergistically to increase the risk of ESCC.METHODS:We performed a systematic literature search in multiple electronic databases regardless of language. Eligible studies were population-based case–control or cohort studies of ESCC that assessed the effects of tobacco and/or alcohol. Departures from multiplicative effects were quantified… CONTINUE READING
    120 Citations

    Figures, Tables, and Topics from this paper.

    Modifiable factors and esophageal cancer: a systematic review of published meta-analyses
    • 34
    • PDF
    Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States
    • 12
    • PDF
    Consumption of garlic and its interactions with tobacco smoking and alcohol drinking on esophageal cancer in a Chinese population
    • Z. Jin, Gina Wallar, +19 authors Z. Zhang
    • Medicine
    • European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
    • 2019
    • 2
    • Highly Influenced
    Risk Factors of Esophageal Squamous Cell Cancer Specific for Different Macroscopic Types
    • 2
    Systematic review: the etiology of esophageal squamous cell carcinoma in low-income settings
    • 3
    • Highly Influenced


    Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma.
    • T. Vaughan, Susan. Davis, A. Kristal, D. Thomas
    • Medicine
    • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
    • 1995
    • 527
    • PDF