The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

@inproceedings{Kim2010TheSE,
  title={The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action},
  author={Tae Hoon Kim and Jinrong Wang and Kevin Y-S Lee and Heather L Franco and Russell R. Broaddus and John P. Lydon and Jae-Wook Jeong and Francesco J. Demayo},
  booktitle={Journal of oncology},
  year={2010}
}
Endometrial cancer is the most common gynecological cancer. Estrogen-dependent endometrioid carcinoma is the most common type of endometrial cancer, and alterations in the expression of PTEN and K-ras have been associated with this disease. To study the roles of Pten and K-ras in endometrial cancer, we generated Pten ablation and oncogenic K-ras mutation in progesterone receptor positive cells (PR(cre/+)Pten(f/f)K-ras(G12D)). Double mutant mice dramatically accelerated the development of… CONTINUE READING

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