The Synechocystis sp. PCC6803 Sfp-type phosphopantetheinyl transferase does not possess characteristic broad-range activity.

@article{Roberts2009TheSS,
  title={The Synechocystis sp. PCC6803 Sfp-type phosphopantetheinyl transferase does not possess characteristic broad-range activity.},
  author={Alexandra A Roberts and Janine N. Copp and Mohamed A. Marahiel and Brett A Neilan},
  journal={Chembiochem : a European journal of chemical biology},
  year={2009},
  volume={10 11},
  pages={1869-77}
}
The cyanobacterium Synechocystis sp. PCC6803 harbours one phosphopantetheinyl transferase (PPTase), Sppt. Protein modelling supported previous bioinformatics analyses, which suggested that Sppt is a Sfp-type PPTase with the potential to phosphopantetheinylate a broad range of carrier proteins from both primary and secondary metabolism. However, no natural products are synthesised by this species, which raises interesting evolutionary and functional questions. Phosphopantetheinylation assays and… CONTINUE READING
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