The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

@article{Chu1996TheSP,
  title={The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.},
  author={Danny Chu and Hergen Spits and J. F. Peyron and R. Bruce Rowley and Joseph B. Bolen and Arthur Weiss},
  journal={The EMBO journal},
  year={1996},
  volume={15 22},
  pages={6251-61}
}
The protein tyrosine phosphatase CD45 is a critical component of the T cell antigen receptor (TCR) signaling pathway, acting as a positive regulator of Src family protein tyrosine kinases (PTKs) such as Lck. Most CD45-deficient human and murine T cell lines are unable to signal through their TCRs. However, there is a CD45-deficient cell line that can signal through its TCR. We have studied this cell line to identify a TCR signaling pathway that is independent of CD45 regulation. In the course… CONTINUE READING
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