The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly.

@article{DonlinAsp2017TheSO,
  title={The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly.},
  author={Paul Gregory Donlin-Asp and Claudia Fallini and Jazm{\'i}n Victoria Quesada Campos and Ching-Chieh Chou and Megan E Merritt and Han C Phan and Gary Jonathan Bassell and Wilfried Rossoll},
  journal={Cell reports},
  year={2017},
  volume={18 7},
  pages={
          1660-1673
        }
}
Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival of motor neuron (SMN) protein. SMN is part of a multiprotein complex that facilitates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). SMN has also been found to associate with mRNA-binding proteins, but the nature of this association was unknown. Here, we have employed a combination of biochemical and advanced imaging methods to demonstrate that SMN promotes the molecular… CONTINUE READING
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