The Sumo protease Senp7 is required for proper neuronal differentiation.

  title={The Sumo protease Senp7 is required for proper neuronal differentiation.},
  author={Francisco Ju{\'a}rez-Vicente and Noelia Luna-Pel{\'a}ez and M. Garc{\'i}a-Dom{\'i}nguez},
  journal={Biochimica et biophysica acta},
  volume={1863 7 Pt A},
  • Francisco Juárez-Vicente, Noelia Luna-Peláez, M. García-Domínguez
  • Published 2016
  • Biology, Medicine
  • Biochimica et biophysica acta
  • Covalent attachment of the Small ubiquitin-like modifier (Sumo) polypeptide to proteins regulates many processes in the eukaryotic cell. In the nervous system, Sumo has been associated with the synapsis and with neurodegenerative diseases. However, its involvement in regulating neuronal differentiation remains largely unknown. Here we show that net Sumo deconjugation is observed during neurogenesis and that Sumo overexpression impairs this process. In an attempt to shed light on the underlying… CONTINUE READING
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