The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy

@inproceedings{Yang2016TheSR,
  title={The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy},
  author={Lei Yang and Di Yu and Ran Mo and Jiru Zhang and Hu Hua and Lvlong Hu and Yu Lin Feng and Song Wang and Wei-yan Zhang and Ning Yin and Xu-ming Mo and Harm Jan Bogaard},
  booktitle={PloS one},
  year={2016}
}
BACKGROUND Pulmonary arterial hypertension is characterized by increased pressure overload that leads to right ventricular hypertrophy (RVH). GPR91 is a formerly orphan G-protein-coupled receptor (GPCR) that has been characterized as a receptor for succinate; however, its role in RVH remains unknown. METHODS AND RESULTS We investigated the role of succinate-GPR91 signaling in a pulmonary arterial banding (PAB) model of RVH induced by pressure overload in SD rats. GPR91 was shown to be located… CONTINUE READING
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