The Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent Polymerases

@inproceedings{Ferrero2015TheSO,
  title={The Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent Polymerases},
  author={Diego S. Ferrero and M{\`o}nica Buxaderas and Jos{\'e} Francisco Rodr{\'i}guez and N{\'u}ria Verdaguer and F{\'e}lix A Rey},
  booktitle={PLoS pathogens},
  year={2015}
}
Thosea asigna virus (TaV), an insect virus belonging to the Permutatetraviridae family, has a positive-sense single-stranded RNA (ssRNA) genome with two overlapping open reading frames, encoding for the replicase and capsid proteins. The particular TaV replicase includes a structurally unique RNA-dependent RNA polymerase (RdRP) with a sequence permutation in the palm sub-domain, where the active site is anchored. This non-canonical arrangement of the RdRP palm is also found in double-stranded… CONTINUE READING

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