The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores.

Abstract

Amphotericin B (AmB) is a polyene macrolide antibiotic isolated from Streptomyces nodosus. The antifungal activity of AmB can be attributed to the formation of an ion-channel assembly in the presence of ergosterol (Erg), in which there are two different AmB-Erg orientations, parallel and antiparallel, as reported previously. In this study, to elucidate the… (More)
DOI: 10.1021/acs.biochem.6b00193

Topics

Cite this paper

@article{Nakagawa2016TheSO, title={The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores.}, author={Yasuo Nakagawa and Yuichi Umegawa and Naohiro Matsushita and Tomoya Yamamoto and Hiroshi Tsuchikawa and Shinya Hanashima and Tohru Oishi and Nobuaki Matsumori and Michio Murata}, journal={Biochemistry}, year={2016}, volume={55 24}, pages={3392-402} }