The Structure of a Retinal-Forming Carotenoid Oxygenase

@article{Kloer2005TheSO,
  title={The Structure of a Retinal-Forming Carotenoid Oxygenase},
  author={Daniel P. Kloer and Sandra Ruch and Salim Al‐Babili and Peter Beyer and Georg E. Schulz},
  journal={Science},
  year={2005},
  volume={308},
  pages={267 - 269}
}
Enzymes that produce retinal and related apocarotenoids constitute a sequence- and thus structure-related family, a member of which was analyzed by x-ray diffraction. This member is an oxygenase and contains an Fe2+-4-His arrangement at the axis of a seven-bladed β-propeller chain fold covered by a dome formed by six large loops. The Fe2+ is accessible through a long nonpolar tunnel that holds a carotenoid derivative in one of the crystals. On binding, three consecutive double bonds of this… 
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