The Structure of a Mycobacterial Outer-Membrane Channel

  title={The Structure of a Mycobacterial Outer-Membrane Channel},
  author={M. Faller and M. Niederweis and G. Schulz},
  pages={1189 - 1192}
  • M. Faller, M. Niederweis, G. Schulz
  • Published 2004
  • Biology, Medicine
  • Science
  • Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two… CONTINUE READING
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