The Structure of a Biologically Active Influenza Virus Ribonucleoprotein Complex

@inproceedings{Coloma2009TheSO,
  title={The Structure of a Biologically Active Influenza Virus Ribonucleoprotein Complex},
  author={Roc{\'i}o Coloma and Jos{\'e} Mar{\'i}a Valpuesta and Roc{\'i}o Arranz and Jos{\'e} L Carrascosa and Juan Ort{\'i}n and Jaime Mart{\'i}n-Benito},
  booktitle={PLoS pathogens},
  year={2009}
}
The influenza viruses contain a segmented, single-stranded RNA genome of negative polarity. Each RNA segment is encapsidated by the nucleoprotein and the polymerase complex into ribonucleoprotein particles (RNPs), which are responsible for virus transcription and replication. Despite their importance, information about the structure of these RNPs is scarce. We have determined the three-dimensional structure of a biologically active recombinant RNP by cryo-electron microscopy. The structure… CONTINUE READING