The Structure of Haplotype Blocks in the Human Genome

@article{Gabriel2002TheSO,
  title={The Structure of Haplotype Blocks in the Human Genome},
  author={S. Gabriel and S. Schaffner and Huy Nguyen and Jamie M Moore and J. Roy and B. Blumenstiel and J. Higgins and M. Defelice and Amy L Lochner and M. Faggart and S. Liu-Cordero and C. Rotimi and A. Adeyemo and Richard Cooper and R. Ward and E. Lander and M. Daly and D. Altshuler},
  journal={Science},
  year={2002},
  volume={296},
  pages={2225 - 2229}
}
Haplotype-based methods offer a powerful approach to disease gene mapping, based on the association between causal mutations and the ancestral haplotypes on which they arose. As part of The SNP Consortium Allele Frequency Projects, we characterized haplotype patterns across 51 autosomal regions (spanning 13 megabases of the human genome) in samples from Africa, Europe, and Asia. We show that the human genome can be parsed objectively into haplotype blocks: sizable regions over which there is… Expand
A haplotype map of the human genome.
A haplotype map of the human genome
Haplotype reconstruction from genotype data using Imperfect Phylogeny
Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome.
Optimal haplotype block-free selection of tagging SNPs for genome-wide association studies.
Haplotype Block Structure Is Conserved across Mammals
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