The Structure of (CENP-A/H4)2 Reveals Physical Features that Mark Centromeres

  title={The Structure of (CENP-A/H4)2 Reveals Physical Features that Mark Centromeres},
  author={Nikolina Sekulic and Emily A. Bassett and Danielle J. Rogers and Ben E. Black},
Centromeres are specified epigenetically, and the histone H3 variant CENP-A is assembled into the chromatin of all active centromeres. Divergence from H3 raises the possibility that CENP-A generates unique chromatin features to mark physically centromere location. Here we report the crystal structure of a subnucleosomal heterotetramer, human (CENP-A–H4)2, that reveals three distinguishing properties encoded by the residues that comprise the CENP-A targeting domain (CATD; ref. 2): (1) a CENP-A… CONTINUE READING

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