The Structure and Diversity of α1-Acid Glycoprotein/Orosomucoid Gene in Africans

@article{Yuasa2006TheSA,
  title={The Structure and Diversity of α1-Acid Glycoprotein/Orosomucoid Gene in Africans},
  author={Isao Yuasa and Hiroaki Nakamura and Kazuo Umetsu and Yoshito Irizawa and L. Susan Henke and J{\"u}rgen Henke},
  journal={Biochemical Genetics},
  year={2006},
  volume={44},
  pages={140-155}
}
Human orosomucoid (ORM), or α1-acid glycoprotein, is known to be controlled by duplicated and triplicated genes on chromosome 9, encoding ORM1 and ORM2 proteins. In this study, the structure and diversity of the ORM gene were investigated in 16 Sub-Saharan Africans, who originated from widely dispersed locations in Africa. The duplicated ORM1-ORM2 gene was observed in all 16 samples. ORM1*S1(2), characterized by an ORM2 gene-specific sequence in intron 5, was common in Africans. Three Africans… CONTINUE READING
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