The Structural Basis of the Allosteric Response and Comparison with Other Allosteric Proteins


Allosteric proteins have vital roles in metabolic regulation and signal transduction. By virtue of indirect interactions between distinct binding sites mediated by the protein molecule, a protein’s activity may be controlled by ligands dissimilar to its own substrate. Classical models of protein cooperativity (1, 2) are based on the concept of multiple… (More)


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