The Structural Basis for Specificity in Protein-Tyrosine Kinase Signaling

@inproceedings{Cantley1996TheSB,
  title={The Structural Basis for Specificity in Protein-Tyrosine Kinase Signaling},
  author={Lewis C. Cantley and Zhou Songyang},
  year={1996}
}
Mammalian cells make decisions to divide, differentiate, adhere, chemotax, secrete, quiesce or apoptose on the basis of their developmental history, extracellular matrix composition, and the presence or absence of growth factors/differentiatiation agents and other cellular activators. From extensive research over the past ten years it has become clear that these decisions are mediated in most cases by the activation of specific protein kinases in the cytosol of the cell. A typical mammalian… CONTINUE READING

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