The Strong Cell-based Hydrogen Peroxide Generation Triggered by Cold Atmospheric Plasma

@article{Yan2017TheSC,
  title={The Strong Cell-based Hydrogen Peroxide Generation Triggered by Cold Atmospheric Plasma},
  author={Dayun Yan and Haitao Cui and Wei Zhu and Annie Talbot and Lijie Grace Zhang and Jonathan H Sherman and Michael Keidar},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
Hydrogen peroxide (H2O2) is an important signaling molecule in cancer cells. However, the significant secretion of H2O2 by cancer cells have been rarely observed. Cold atmospheric plasma (CAP) is a near room temperature ionized gas composed of neutral particles, charged particles, reactive species, and electrons. Here, we first demonstrated that breast cancer cells and pancreatic adenocarcinoma cells generated micromolar level H2O2 during just 1 min of direct CAP treatment on these cells. The… 
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TLDR
This review discusses the cellular changes appearing in cell membranes, cytoplasm, various organelles, and DNA content upon cells’ direct or indirect exposure to CAP or CAP-activated media/solutions (PAM), respectively.
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