The Stress Kinase p38α as a Target for Cancer Therapy.

  title={The Stress Kinase p38α as a Target for Cancer Therapy.},
  author={Ana Igea and Angel R Nebreda},
  journal={Cancer research},
  volume={75 19},
p38α is a ubiquitous protein kinase strongly activated by stress signals, inflammatory cytokines, and many other stimuli, which has been implicated in the modulation of multiple cellular processes. There is good evidence in the literature that p38α plays an important tumor-suppressor role by interfering with malignant cell transformation. This is mainly based on the ability of the p38α pathway to regulate tissue homeostasis by integrating signals that balance cell proliferation and… CONTINUE READING

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