The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules.

@article{Khong2017TheSG,
  title={The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules.},
  author={Anthony Khong and Tyler Matheny and Saumya Jain and Sarah F. Mitchell and Joshua R Wheeler and Roy Parker},
  journal={Molecular cell},
  year={2017},
  volume={68 4},
  pages={
          808-820.e5
        }
}
Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress granules are important in the stress response and may contribute to some degenerative diseases. Here, we describe the stress granule transcriptome of yeast and mammalian cells through RNA-sequencing (RNA-seq) analysis of purified stress granule cores and single-molecule fluorescence in situ hybridization (smFISH) validation. While essentially every mRNA, and some noncoding RNAs (ncRNAs), can be targeted to… CONTINUE READING
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