The Streptomyces tendae Tü901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis.

@article{Bruntner1998TheST,
  title={The Streptomyces tendae T{\"u}901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis.},
  author={Christina Bruntner and Christiane Bormann},
  journal={European journal of biochemistry},
  year={1998},
  volume={254 2},
  pages={347-55}
}
Protein P8 was previously identified as a putative nikkomycin biosynthesis protein. The gene (nikC) encoding protein P8 was cloned from the Streptomyces tendae Tü901 nikkomycin gene cluster and sequenced. The nikC gene was inactivated by inserting a kanamycin resistance cassette; the mutant did not produce the biologically active nikkomycins I, J, X, and Z, but accumulated the nucleoside moieties nikkomycins C(X) and C(Z). The mutant was complemented to nikkomycin production (I, J, X, Z) by… CONTINUE READING
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