The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production.

@article{Lomovskaya1996TheSP,
  title={The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production.},
  author={Natalia Lomovskaya and Seong Karp Hong and Sung Uk Kim and Leonid Fonstein and Keiko Furuya and Richard C. Hutchinson},
  journal={Journal of bacteriology},
  year={1996},
  volume={178 11},
  pages={3238-45}
}
The drrC gene, cloned from the daunorubicin (DNR)- and doxorubicin-producing strain of Streptomyces peucetius ATCC 29050, encodes a 764-amino-acid protein with a strong sequence similarity to the Escherichia coli and Micrococcus luteus UvrA proteins involved in excision repair of DNA. Expression of drrC was correlated with the timing of DNR production in the growth medium tested and was not dependent on the presence of DNR. Since introduction of drrC into Streptomyces lividans imparted a DNR… CONTINUE READING

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