The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli

@article{Godar2019TheSI,
  title={The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli},
  author={S. C. Godar and R. Cadeddu and G. Floris and L. Mosher and Zhen Mi and D. P. Jarmolowicz and Simona Scheggi and A. Walf and C. Koonce and C. Frye and N. Muma and M. Bortolato},
  journal={Biomolecules},
  year={2019},
  volume={9}
}
  • S. C. Godar, R. Cadeddu, +9 authors M. Bortolato
  • Published 2019
  • Medicine
  • Biomolecules
  • Finasteride (FIN) is the prototypical inhibitor of steroid 5α-reductase (5αR), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. FIN is clinically approved for the treatment of benign prostatic hyperplasia and male baldness; while often well-tolerated, FIN has also been shown to cause or exacerbate psychological problems in vulnerable subjects. Evidence on the psychological effects of FIN, however… CONTINUE READING
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