The Steroid Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is Important for Pathogenesis and a Target for Vaccine Development

@inproceedings{Geize2011TheSC,
  title={The Steroid Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is Important for Pathogenesis and a Target for Vaccine Development},
  author={Robert van der Geize and A. W. F. Grommen and Gerda I Hessels and Antonius Arnoldus Christiaan Jacobs and Lubbert Dijkhuizen},
  booktitle={PLoS pathogens},
  year={2011}
}
Rhodococcus equi causes fatal pyogranulomatous pneumonia in foals and immunocompromised animals and humans. Despite its importance, there is currently no effective vaccine against the disease. The actinobacteria R. equi and the human pathogen Mycobacterium tuberculosis are related, and both cause pulmonary diseases. Recently, we have shown that essential steps in the cholesterol catabolic pathway are involved in the pathogenicity of M. tuberculosis. Bioinformatic analysis revealed the presence… CONTINUE READING
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 68 REFERENCES

A novel method to generate unmarked gene deletions in the intracellular pathogen Rhodococcus equi using 5-fluorocytosine conditional lethality

  • R Van der Geize, W de Jong, GI Hessels, AW Grommen, AA Jacobs
  • Nucleic Acids Res
  • 2008
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…