The Steap proteins are metalloreductases.

@article{Ohgami2006TheSP,
  title={The Steap proteins are metalloreductases.},
  author={Robert S Ohgami and Dean R Campagna and Alice A McDonald and Mark D Fleming},
  journal={Blood},
  year={2006},
  volume={108 4},
  pages={
          1388-94
        }
}
Iron and copper are essential for all organisms, assuming critical roles as cofactors in many enzymes. In eukaryotes, the transmembrane transport of these elements is a highly regulated process facilitated by the single electron reduction of each metal. Previously, we identified a mammalian ferrireductase, Steap3, critical for erythroid iron homeostasis. Now, through homology, expression, and functional studies, we characterize all 4 members of this protein family and demonstrate that 3 of them… CONTINUE READING

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