Highly Influenced
6 Excerpts
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.
- Published 2006 in Science
Abstract
Scaffold proteins organize signaling proteins into pathways and are often viewed as passive assembly platforms. We found that the Ste5 scaffold has a more active role in the yeast mating pathway: A fragment of Ste5 allosterically activated autophosphorylation of the mitogen-activated protein kinase Fus3. The resulting form of Fus3 is partially active-it is… (More)