The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

@article{Chan2005TheSK,
  title={The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1},
  author={Eunice H. Y. Chan and Marjaana Nousiainen and Ravindra B. Chalamalasetty and A J Sch{\"a}fer and Erich A. Nigg and Herman H. W. Sillj{\'e}},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={2076-2086}
}
Originally identified in Drosophila melanogaster, the Warts(Wts)/Lats protein kinase has been proposed to function with two other Drosophila proteins, Hippo (Hpo) and Salvador (Sav), in the regulation of cell cycle exit and apoptosis. In mammals, two candidate Warts/Lats homologs, termed Lats1 and Lats2, have been described, and the targeted disruption of LATS1 in mice increases tumor formation. Little, however, is known about the function and regulation of human Lats kinases. Here we report… 

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TLDR
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TLDR
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TLDR
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