The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis.

@article{Patti1994TheSA,
  title={The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis.},
  author={Joseph M. Patti and Tomas Bremell and D Krajewska-Pietrasik and Arturo Abdelnour and Andrzej Tarkowski and Cecilia Ryd{\'e}n and Magnus H{\"o}{\"o}k},
  journal={Infection and immunity},
  year={1994},
  volume={62 1},
  pages={152-61}
}
The importance of a collagen-binding adhesin in the pathogenesis of septic arthritis has been examined by comparing the virulence of two sets of Staphylococcus aureus mutants in an animal model. Collagen adhesin-negative mutant PH100 was constructed by replacing the chromosomal collagen adhesin gene (cna) in a clinical strain, Phillips, with an inactivated copy of the gene. Collagen adhesin-positive mutant S. aureus CYL574 was generated by introducing the cna gene into CYL316, a strain that… CONTINUE READING