The Stability of the Blood Oxygenation Level-Dependent Functional MRI Response to Motor Tasks Is Altered in Patients With Chronic Ischemic Stroke

  title={The Stability of the Blood Oxygenation Level-Dependent Functional MRI Response to Motor Tasks Is Altered in Patients With Chronic Ischemic Stroke},
  author={Kelley C. Mazzetto-Betti and Renata Ferranti Leoni and Oct{\'a}vio Marques Pontes-Neto and Ant{\^o}nio Carlos dos Santos and Jo{\~a}o Pereira Leite and Afonso C. Silva and Draulio B. de Araujo},
Background and Purpose— Functional MRI is a powerful tool to investigate recovery of brain function in patients with stroke. An inherent assumption in functional MRI data analysis is that the blood oxygenation level-dependent (BOLD) signal is stable over the course of the examination. In this study, we evaluated the validity of such assumption in patients with chronic stroke. Methods— Fifteen patients performed a simple motor task with repeated epochs using the paretic and the unaffected hand… 

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