The Src-suppressed C kinase substrate, SSeCKS, is a potential metastasis inhibitor in prostate cancer.

@article{Xia2001TheSC,
  title={The Src-suppressed C kinase substrate, SSeCKS, is a potential metastasis inhibitor in prostate cancer.},
  author={Wei Xia and P P Unger and Lance Miller and Jonas Nelson and Irwin H. Gelman},
  journal={Cancer research},
  year={2001},
  volume={61 14},
  pages={5644-51}
}
The molecular mechanisms leading to prostate cancer remain poorly understood, especially concerning the progression to the metastatic form. SSeCKS, a major protein kinase C substrate with tumor suppressor activity, is likely the rodent orthologue of human Gravin/AKAP12, a scaffolding protein for protein kinases A and C. Gravin was mapped as a single-copy gene to 6q24-25.2, a hotspot for deletion in advanced prostate cancer, and therefore, we investigated the role of SSeCKS/Gravin in prostate… CONTINUE READING
47 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

SSeCKS AS METASTASIS INHIBITOR IN PROSTATE CANCER Research

  • T. R. Tennant, H. Kim, M. Sokoloff, C. W. Rinker-Schaeffer
  • The Dunning model. Prostate,
  • 2000

Similar Papers

Loading similar papers…