The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.

@article{Tatton2003TheSK,
  title={The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.},
  author={Louise Tatton and Gary M Morley and Rajesh K. Chopra and Asim A. Khwaja},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 7},
  pages={4847-53}
}
4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]- pyrimidine (PP1) was identified as an Src-selective tyrosine kinase inhibitor and has been used extensively to investigate signaling pathways involving Src kinases, including events downstream of the stem cell factor (SCF) receptor c-Kit. While investigating the role of Src kinases in SCF signaling, we found that PP1 completely abrogated the proliferation of M07e cells in response to SCF. PP1 inhibited SCF-induced c-Kit autophosphorylation… CONTINUE READING

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