The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1.

@article{Nomme2011TheSH,
  title={The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1.},
  author={Julian Nomme and Alan S. Fanning and Michael Caffrey and Ming F Lye and James Melvin Anderson and Arnon Lavie},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 50},
  pages={43352-60}
}
Tight junctions are cell-cell contacts that regulate the paracellular flux of solutes and prevent pathogen entry across cell layers. The assembly and permeability of this barrier are dependent on the zonula occludens (ZO) membrane-associated guanylate kinase (MAGUK) proteins ZO-1, -2, and -3. MAGUK proteins are characterized by a core motif of protein-binding domains that include a PDZ domain, a Src homology 3 (SH3) domain, and a region of homology to guanylate kinase (GUK); the structure of… CONTINUE READING
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