The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.

@article{Xiang2012TheSF,
  title={The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.},
  author={Binggang Xiang and Guoying Zhang and Lucia Stefanini and Wolfgang Bergmeier and Theodore Kent Gartner and Sidney W Whiteheart and Zhenyu Li},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 49},
  pages={41277-87}
}
The Src family kinases (SFKs) play essential roles in collagen- and von Willebrand factor (VWF)-mediated platelet activation. However, the roles of SFKs in G protein-coupled receptor-mediated platelet activation and the molecular mechanisms whereby SFKs are activated by G protein-coupled receptor stimulation are not fully understood. Here we show that the thrombin receptor protease-activated receptor 4 agonist peptide AYPGKF elicited SFK phosphorylation in P2Y(12) deficient platelets but… CONTINUE READING
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